A simple blood test could predict not only a persons risk of developing , but also the year symptoms will begin.
Researchers at the Washington University School of Medicine in St. Louis set out to determine if levels of a specific protein in the blood could be used as a “biological clock” to predict when signs of the disease will emerge.
The specific protein, known as p-tau217, forms “tangles” in the brain that disrupt communication between nerve cells. In a healthy brain, tau helps to stabilize the structure of .
In some cases, can be used to detect these tangles when diagnosing Alzheimers. Preliminary studies have suggested that the same method could be used to determine a progression timeline.
As these imaging tests are often complex and expensive, the research team wanted to explore whether a blood test could monitor the same proteins and produce similar results.
The study, published in the journal Nature Medicine, analyzed data from more than 600 enrolled in two long-term Alzheimers research projects.
By comparing blood samples with participants cognitive performance over several years, the team found that p-tau217 levels rise in a “remarkably consistent” pattern long before memory loss begins, according to a press release.
The team then created a model that uses a patient’s age and protein levels to estimate when symptoms will appear, with a margin of error of three to four years.
“We show that a single blood test measuring p-tau217 can provide a rough estimate of when an individual is likely to develop symptoms of Alzheimers disease,” lead author Kellen K. Petersen, PhD, instructor of neurology at Washington University in St. Louis, told Fox News Digital.
The researchers found that older adults much more rapidly after p-tau217 became abnormal, he noted.
“For example, people who first had abnormal p-tau217 levels around age 60 didnt develop Alzheimers symptoms for about 20 years, whereas those who first had abnormal p-tau217 levels around age 80 developed symptoms after only about 10 years,” Petersen said.Â
This suggests that age and disease-related changes in the brain can influence how quickly Alzheimers symptoms become apparent, the researcher concluded.
“This could transform how researchers design clinical trials and, eventually, how clinicians identify people at highest risk for associated with Alzheimers years before decline begins,” Chicago-based Rebecca M. Edelmayer, PhD, vice president of scientific engagement at the Alzheimers Association, told Fox News Digital.
“A blood test is generally much less expensive and easier to administer than a brain scan or spinalâfluid test. In the future, it could help doctors and researchers identify people who may benefit from ,” added Edelmayer, who was not involved in the study.
The study did have some limitations and caveats.
“We were only able to make predictions for individuals whose p-tau217 levels fell within a certain range, although it was a fairly wide range,” Petersen shared. “The models were developed in and well-educated research cohorts that were not diverse, so the results may not apply well to the broader population.”
While the researchers referenced in-home blood tests , they cautioned against people seeking out and taking these tests themselves.
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“At this point, we do not recommend that any cognitively unimpaired individuals have any biomarker test,” Dr. Suzanne Schindler, a neurologist at Washington University who was a co-author of the study, said in the press release.
Peterson acknowledged that these results are still experimental and ripe for improvement.
“The current estimate is not yet accurate enough for or personal medical decision-making, but we expect that it will be possible to create more
